NBC: Neighborhood Breakpoint Conservation


Neighborhood Breakpoint Conservation (NBC) is a method that identifies recurrent copy number variants in multiple individuals using Array Comparative Genomic Hybridization (aCGH).

aCGH computes the ratio of test:reference DNA for probes located on the reference genome. NBC first uses a Bayesian changepoint algorithm to identify probes, called breakpoints, that change from low-to-high or high-to-low copy number with high probability. A binomial statistic is then applied to identify breakpoints and pairs of breakpoints that appear in a statistically significant number of individuals.



A. Ritz, P.L. Paris, M.M. Ittmann, C. Collins, and B.J. Raphael. (2011) Detection of Recurrent Rearrangement Breakpoints from Copy Number Data. BMC Bioinformatics. [Publisher Link]