paste3.helper.pca_distance

paste3.helper.pca_distance(a_slice, b_slice, n_top_genes, latent_dim)

Computes pairwise distances between two distributions slices after dimensionality reduction using PCA.

Parameters:

• a_slice (AnnData) -- AnnData object representing the first slice.

• b_slice (AnnData) -- AnnData object representing the second slice.

• n_top_genes (int) -- Number of highly variable genes to select for PCA.

• latent_dim (int) -- Number of principal components to retain in the PCA reduction.

Returns:

distances -- Distances between the two distributions after dimensionality reduction

Return type:

np.ndarray